RESEARCH ARTICLE


Bone Regenerative Potential of Mesenchymal Stem Cells on a Micro- Structured Titanium Processed by Wire-Type Electric Discharge Machining



Yukimichi Tamaki*, Yu Kataoka, In-Kee Jang, Takashi Miyazaki
Department of Oral Biomaterials and Technology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.


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© 2010 Tamaki et al;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Oral Biomaterials and Technology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; E-mail: tamaki@dent.showa-u.ac.jp


Abstract

A new strategy with bone tissue engineering by mesenchymal stem cell transplantation on titanium implant has been drawn attention. The surface scaffold properties of titanium surface play an important role in bone regenerative potential of cells. The surface topography and chemistry are postulated to be two major factors increasing the scaffold properties of titanium implants. This study aimed to evaluate the osteogenic gene expression of mesenchymal stem cells on titanium processed by wire-type electric discharge machining. Some amount of roughness and distinctive irregular features was observed on titanium processed by wire-type electric discharge machining. The thickness of suboxide layer was concomitantly grown during the processing. Since the thickness of oxide film and micro-topography allowed an improvement of mRNA expression of cells, titanium processed by wire-type electric discharge machining is a promising candidate for mesenchymal stem cell based functional restoration of implants.

Keywords: Titanium, implant, surface, mesenchymal stem cell.